????? ??? ?? ???,
??? ?????? ??? ???癌转移) ?? ??
????(?? ???) ????? ??? ?? ???? (?)???????? ? ?????????? ?? ??? “???????? ??? ??? ???? ???? ???? ??? ?? ??? ??”?? ??? ??? ??? ??? ???? ??? Nature Cell Biology(IF: 20.06) 9? 11?? ????? ?????? ???.
????? “?? ?? ? ??? ???? A20 ???? ??? ??·??? ??? Snail1 ????? ?? ???????? ?????? ???????? ???? ????? ??? ?? ??? ??”???.
? ??? ?? A20 ???? Snail1 ???? ????? ????? Snail1 ???? 3?? ?? ????? ??????? ??? ????. ??? Snail1? ???????? Snail1 ???? ?????? GSK3β?? ????? ??? ???? ??, ?? ????? ? ??? Snail1 ???? ???? ?????? ???? ??? ? ??? ??? ?????. ?? A20 ??? ??? ??????? ???? ???? ??? ???? doxorubicin? docetaxel? ?? ????? ??? ???? ?????.
??? ??? ??? ??? “? ??? A20 ???? Snail1 ????? ????? ????? ???? ??? ???? blocker? ?? ?? Snail1? ??????? ??? ??? ??? ??? ?????? ?? ???????? ??? ??? ???? ??? ??? ??? ??? ??? ??? ????”?? ??? ??? ????.
? ??? ????? ??????????? ? ????????? ????????(????)?? ??? ?????, ? ????? ??? ????? ??????? ?? ??? ?? ???? Nature Cell Biology (??? ? ?????, IF: 20.06) 9? 11?? ????? ?????.
(?? 1) ?????????? A20? ???? ??? ???
(?? 2) A20? ?? Snail1 ???? ?? ???????
??? ??? ??? ??? ??? ??
??
