??? ??? ?? ???,
miRNA? ??? ???? ??? ? ?????
RNA?? ????? ??
[??] ??? ??, ??? ??, ??? ????, ??? ????
??? ??? ?? ???(?1?? ??? ??)? ??? ????? ???? ???? ??? ??? ??? ???? ????. ?? ??? ?? ?? ??? Ninj1? ??? ???? miRNA 125a-5p? ??? ??? ???.
Ninjurin1(Ninj1) ???? ????? ???? ?? ????? ??? ????? ??? ? ??? ??? ??? ? ????????? ????? ???? ???? ??? ??? ??? ??. ??? ???? ????????? ???? ???? Ninj1? ??? ??? ????? ??? ?? ??.
?? ???? Ninj1?? ????? ??????? ?????? ???? ??????, miRanda ????? ???? ??? ?? Ninj1? ???? 5?? miRNA? ????. ?? miR-125a-5p? Ninj1 ??? ?? ??? ?? ??? ???, ??? ??????? ???? ???? ???? Ninj1? ???? ????? ??? ???????, ??? ??? ????? ?? ????.
??? ??? “?? ?? ??? ??? ???? ???? ??????? ??? ? ??? ???? ????? ???? ???”??? “??? ????? ?????????? ????? ????? ???? ?? ??? ???? ??? ? ?? ?”??? ????.
? ??? ??????? ???? ???????????? ??????????????? ???? ??????, ??? ?? ??? ???? Cell Death & Differentiation(IF 15.828, JCR ranking 3.7%) 6??? ?????.
※ ??? : miR-125a-5p attenuates macrophage-mediated vascular dysfunction by targeting Ninjurin1
- ?? : ???(?1??), ???(????), ???(????), ???(????), ???(????), ???(????), ???(????), ???(????)
[????] miR-125a-5p? ?? ?? ??
(?) ??????? ???? Ninj1? ??? ???? ??, ????? (Ninj1+/+)? Ninj1 ?? ??? (Ninj1-/-)? 3?, 5?, 7?? ????? ???? Flat mount ???? ?? ??? GS-lectin? ???? ??. ?? ??? ?? ???? ?????? Ninj1 ?? ???? ????? ????? ???? ??? ??? ?? ?? ??? ? ??.
(?) ??? ?? ????? Blood retinal barrier (BRB)? ????? ????????? ???? ?? ? ??? ???? ?? ???? ????. Ninj1? ??? ???? miR-125a-5p? ??? ??? ?????? ???? ??, ???? (FITC)? ??? dextran? ??? ??? ????? ?, Flat mount ???? ????. ? ??, ??? (Normal)? ?? ???? ????? (DM)?? ??? ???? ?? ????? ??? dextan? ?? ??? ??????, miR-125a-5p ????? ?? ??? ????? ????? ??? dextran? ??? ???? ????. ??? ??? ???, Ninj1? ??? ???? miR-125a-5p? ??? ?? ??? ???? ???? ??? ???? ??? ? ??? ??? ? ??.
??
