????/?????? ??? ?? ???,
???? ??? ??? ??? ???? ?? ??
- ?? ?? T ?????? ?? ???????? ?? ?? ??
[??] ??? ??, ??? ??(????)
??????(?? ???) ????/?????? ??? ?? ???(?1?? ???)? ????? ???? ??? ?? ???(?? ?1?? ???)? ?? ???? ???(exosome) ?? ? ??? ???? ??? ???? ???????? ??? ?? ????? ???? ??? ????.
???????(immune checkpoint inhibitor)? ?? ?? T??(cytotoxic T cell)? ??? ???? ???? ???????, ???, ????, ??, ??? ? ??? ? ?? ??? ??. ??, ?? ?? ? ??? ????? ??? ??? ?? 3?? ???? ???? ???, 2018? ?? ?????? ??? ?? ?????. ??? ??? ?? ???? ??????? ??? ??? ??? 15-45%? ??? ??? ?? ???? ???? ??? ?? ??? ?? ????.
[?? 1] SFX? aPD-L1 ??? ???? ???
?? ???????? ?? ?? ??? ??? ??? PD-L1(exosomal PD-L1)? ?????. ?????? ??? ??? PD-L1? ??? ?? ??? ????? ?? ?? T??? ??? ???? ???????? ??? ???? ??? ??? ??. ?, ???? ??? PD-L1? ??? ? ??? ???? ????? ???? ??? ??? ???? ?????? ???? ??? ?? ?? ???.
[?? 2] ??? ?? ?? ? ?? ?? ?? ??
?????? ? ??? ??? ??? ??? ? ??? ???????? ??? ??? ? ?? ??? ????, ??? ???? ?? ??? ???? ????????(high throughput screening)? ??? ??? ???? ???? ?? ????? (sulfisoxazole, SFX)? ????? ???? ??? ?????. ? ??, SFX? ???? ??? PD-L1 ??? ????? ?????, ??? ?? ??? T ??? ???? ???? ?????. ??, ????? ?? ???????? SFX? ?? ??? T ?? ??? ??????? ???? ?? ?? ?? ?? ?? ??? ?? ???? ? ??? ?????.
??? ??? ??? ??? "???? ??? PD-L1 ???? ??? ?? SFX? ???????? ??? ?? ??? ??? ??? ???? ?? ????, ?? ???????? ???? ??? ??? ??? ???? ?? ? ??? ????”? ??? ??? ?????. ?? SFX? ??? ??? ??? ??? ??????? ?? ????, ??? ?????? ??????? ?????? ?? ?? ??? ????(1/2a ?)? ?? ???. ???? ?? ??? SFX? ???? ???-?????(Polymer-Drug Conjugate, PDC)? ??-?????(Antibody-Drug Conjugate, ADC)??? ????? ??? ???? ??.
? ????? ??????????? ???? ??????????? ???? ??????, ?? ??? `????? ????(Advanced Science, IF 16.806)'? 12? 20?(?) ?????.
※ ???
: Sulfisoxazole elicits robust antitumour immune response along with immune checkpoint therapy by inhibiting exosomal PD-L1
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