??? ??? ???, ????? ??? ?????
???? ????? ?? ??
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??????(?? ???)? ??? ??? ?? ???? ?? ???? ?? ????? ???? ?? ??? ????? ?????? ????? ???.
?? ??? ???? ??? ???? ?, ????? ?? ?? ???????? ?? ?? ?????(??-??????)????? Glyoxalase Ⅰ? Ⅱ ??? ????? ?? ??? ??? ??? (lactic acid)? ?? ??-??????? ??? ??.
???? ??? ??? ???? Glyoxalase I ??? ?? ???? ???????? (?????? ??????? ?? ???)? ??? ???? ??? ?????, ?? ??? ?? ??? ?? ????? ??????? ??? ? ??? ??? ????? ???? ?? α-hydroxythioester ????? ?? ???? ?? ??????? ??? ? ?? ???? ????? ???? ???? ??? ??? ??? ?????? ‘??? ???????’ 4? 4? ?? ????.
????? ???? ???? ???? ?? ???????(chiral drugs)? ???? ? ????, ???? ? ??? ????? ?? ?? α-hydroxythioesters ? ????? ????? ?? α-hydroxyamides ???? ????? ?????? ??? ???? ???? ??? ????? ????.
???? “???? ??????? ??? ????? ??? ???? ?????? ??? ?? ??? ??? ????? ?? ?? ????? ??? ? ?? ??? ??? ????? ??? ??? ???? ??.”?? “??? ??? ??? ??? ????? ??????? ?? ?? ? ???? ?? ??? ??? ????? ??? ??? ????.”? ???. ?? ???? “??? ?? ??????? ?? ????? ????? ???? ???? ?? ??? ??? ?? ?????? ???? ???? ?? ??? ?????, ?? ????? ????? ??? ??????? ??? ???? ??? ?? ?? ??? ????? ????? ???.
??? ???? ?? ???? ??? ???? ?????, ?? ?? (2012?, 2013?, 2015?) ‘????’ ?? “??? ???????’?? ???? ??.
???? “Biomimetic Catalytic Transformation of Toxic α-Oxoaldehydes to High-Value Chiral α-Hydroxythioesters using Artificial Glyoxalase I” (?1?? ???, ?2?? ???, ?3?? ???, ???? ???).
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