??? ??????? ?? ?????, ?? ??? ???? ??
“?? ??? ??? ??? ??? ????
???? ?? ? ???? ?? ?? ??? ??? ??? ?? ”
???? ??? ??? ?? ???? ????? ? ????? ???? ?? ??? ??? ?? ??? ??? ??? ????, ????? ?? ? ???? ??? ?? ????? ??? ??? ?????.
???? ?? ??? ??? ??? ???? Wnt (??) ??????? Cdon? ??? ???? ???? ??? ???? ?? ?????? ???? ?? ??? ??? ??? ????? Cdon? ??? ?? Wnt? ?? ??? ?? ??? ???? ??????, ??? Wnt ??? Cdon? ??? ??? ??? ??? ???? ??? ??? ????? ?? ?????.
? ????? ??? ???? ???? Cdon ???? ????? ? Wnt ??? ???? ? ?? ???? b-catenin? ??? ?? ??? ?? ??? ??? ???? ??? ??? ??? ???? ??? ?????. ?? ?? ???? ???? ???? ????????? ????? ??? ??? ????? ??????, ? ?? Cdon? ??? ????? ???? ???? ??? ??? ?????? ?????. ?? Cdon ???? Wnt ??? ???? ??? ???? ??? ???? ????? ?? ??? ??? ??? ?? ????.
Wnt ????? ??????? ?? ??? ????? ??? ? ???? ???? ?? ?? ? ??? ????? ????, ????? ???? ??? ??? ????. ?? Wnt ????? ????? ????? ?????? ??? ??? ???? ???? ??? ????, ? ???? ??? ???? ??? ??? ??? ??? ?? ?? ? ??? ??? ? ?? ??? ????, ??? ??? ???? ????? ?? ? ?? ??? ???? ??? ??? ????.
? ??? ????? ????????? ??? ?? ???? ??? ??????? ????? ??? ?? ???? ??? ??????? ??? ??????, ???????? ???? ????? ????? ???? ????? ???? ???? ????? ??? ?? ???? ??????? (Proceedings of the National Academy of Sciences)誌 ????? 2? 2??? ?????.
※ ???: Cdon deficiency causes cardiac remodeling through hyperactivation of WNT/β-catenin signaling.
Cdon ?? ??? ???? ?????? ???
Cdon? ??? ????????? ???? ??? ?? Wnt? ????? ? ???.
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