?? ??
?????? ?? ????? ???? ? ??
?? ?????? ??‘???’??? ??? ??
???? ?? ?? ???? ??? ??? ?? ??
‘TGF-beta’?? ??????? ?? ???? ?? ????? ??? ?????
??? ??? ?? ???? ??? ?? ‘???’ ???? ‘??? ???????’
10??? ????.
????? “Smad6 inhibits non-canonical TGF-beta1 signaling by recruiting
the deubiquitinase A20 to TRAF6 (Smad6 ???? ?????? ?? A20 ????
????? ?? TGF-beta1 ?? ???? ????? ????)”.
????? ?????(?????.????)? ??? ?????(?1??)?
TGF-beta? ?? ????(noncanonical) ???? ??? ??? ‘Smad6’ ????
‘A20’??? ?????? ??? ?? ?????? ?? ???? ??? ???.
TGF-beta? ??? ??? ??? ?? ??? ????? ???? ?????,
TGF-beta? ?? ??? ?????? ???? ? ??? ???? ?? ???
???? ??? ??? ??. TGF-beta? ?? ?? ???? ??? ‘??? ???’?
???? ???(canonical) ??? ??? ???? ???? ?? ???? ???
???? ??? ?????, ???? ?? ????? ??? ????? ??
????? ?? ???.
? ??? ?? ? ??? Smad6? A20 ???? ????? ?? ???? TGF-beta
????? ???? ??? ?????? ???? ????? ??? ????
??? ???? ???? ????? ???? ??? ??? ?? ??? ????
????? ??. ?????? “TGF-beta??? ?? ???? ???? ?? ????
???? ??? ??? ?? ??? ??? ??? ?? ???? ??”?? ???.
? ??? ??????? ??????? ? ??????? ???????
????? ???? ????.
??
