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2010.04.08
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?????? ?? ‘? ?????’ ?? ?? ???? ??? ??? ??? ???? ??(因子)??? ??? ???? ???? ???? ??? ??, ??? ??? ??? ??? ????? ?????? ??????? ??? ?? ??? ??? ??? ???? ??.
?????? ???? ????? ???? ????? ??????? ????? ???? ??????? ?? ??? ???? ???? ‘?????’(CREBH)? ??? ??? ?? ??? ?? ????? ??? ?? ?? ??, ??? ?????? ???? ?? (RNA interference)??? ??? ? ????? ???? ???? ??? ???? ?? ??? ??? ???? ??? ?? ???? ???? ‘? ?????’(Cell Metabolism) 4??? ????. ? ???? ?? ???? ??? ????? ???? ???? ?????(Optical in vivo imaging)? ???? CREBH? ????? ?? G6Pase? ????? ???? ??? ??? ?????? ?? ???? ??? ???? ????? ??? ? ?? ??? ??? ??? ??? ????.
????? ???? ??? 3??? ??? ?? ?? ? ?????? ?? ????? ??? ‘??2’(TORC2/CRTC2)? CREBH? ??? ???? ??? ??? ??? ???? PEPCK? G6Pase? ????? ????? ?? ???? ??? ‘? ?????’? ??? ????? ??. ???? : Regulation of hepatic gluconeogenesis by an ER-bound transcription factor, CREBH. Cell Metabolism(SCI IF = 16.107)
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